The use of Microwave Irradiation in Peptide Chemistry

Paolo Grieco - Article published in Chemistry Today

Abstract
The introduction of high-throughput biological screening and the accelerated discovery of new biological targets has increased the demand on synthetic chemists to produce new compounds for testing. One response to this demand has been the development of new techniques to greatly increase the speed and efficiency of compound synthesis. In the case of peptides combinatorial libraries containing large numbers of individual components have afforded high-affinity ligands and potent inhibitors to a variety of targets. Recently there has been growing interest in applying microwave heating for many chemical applications requiring energy input. In this paper, we will review the most interesting examples of microwave-promoted reactions in peptides and peptidomimetics synthesis.

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