Synthesis of 4,5-dihydroisoxazoles from N-nitroso-4,5 dihydropyrazoles under Microwave Irradiation

Kostikov R.R., Stepakov A.V., Galkin I.A and Molchanov A.P., St. Petersburg State University

Introduction

4,5-Dihydroisoxazoles have been used as key intermediates in the synthesis of a bioactive molecules and are found in pharmaceutical agents such as glycoprotein IIb/IIIa (GPIIb/IIIa) inhibitors and human leukocyte elastase inhibitors. In the present work 4,5-dihydroisoxazoles have been prepared by thermal removal of nitrogen from N-nitroso-4,5-dihydropyrazoles under microwave irradiation.

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