Posters from MAOS 2006
Microwave Mediated Stereoselective Chelation-Controlled Heck-Reactions
Stefanie Schlummer, Jonas Sävmarker, Peter Nilsson and Mats Larhed. Uppsala University
Palladium-catalyzed coupling reactions of the Heck type have emerged as one of the most versatile carbon-carbon bond forming processes. However, despite the extensive use of the Heck coupling, the reaction still suffers from some limitations such as unsatisfactory control of stereoselectivity. One approach to circumvent this problem is the use of chiral auxiliaries.
A Preparative Microwave Method for the Isomerisation of 4,16-Dibromo[2.2]Paracyclophane Into 4,12-Dibromo[2.2]Paracyclophane1
D. Christopher Braddock, Simon M. Ahmad and Gordon T. Douglas. Imperial College London
The microwave power treatment unit is based on direct transfer of microwave energy and selective absorption of microwaves in processing materials. The characteristics of selectivity and direct transfer induce a considerable energy saving with respect to classical technologies, but it depends on the nature of the mixture.
Microwave Accelerated Heterogeneous Catalysis – Flow-Through Reactor Concept and Application
T. Glasnov, K. Mennecke, R. Cecillia, U. Kunz, A. Kirschning and C.O. Kappe,. Karl-Franzens University, University of Hannover and Technical University of Clausthal
Flow-through processes in organic synthesis become more important as an enabling technology for a cost effective and convenient method. This requires appropriate reactors with functionalities for organic reactions. In this project noble metal-loaded polymer/carrier reactors able to be operated in a microwave field were investigated. By application of a microwave field metal sites are heated whereas the polymer/carrier material remains transparent to irradiation.
Synthesis of 4,5-dihydroisoxazoles from N-nitroso-4,5 dihydropyrazoles under Microwave Irradiation
Kostikov R.R., Stepakov A.V., Galkin I.A and Molchanov A.P.. St. Petersburg State University
4,5-Dihydroisoxazoles have been used as key intermediates in the synthesis of a bioactive molecules and are found in pharmaceutical agents such as glycoprotein IIb/IIIa (GPIIb/IIIa) inhibitors and human leukocyte elastase inhibitors. In the present work 4,5-dihydroisoxazoles have been prepared by thermal removal of nitrogen from N-nitroso-4,5-dihydropyrazoles under microwave irradiation.
The Benefits of Automation in Microwave-Assisted Workflows
F. Wiesbrock, R. Hoogenboom, D. Elend and U.S. Schubert. Eindhoven University of Technology and Dutch Polymer Institute and Chemspeed Technologies AG
The microwave-assisted polymerizations of 2-oxazolines as well as the subsequent analyses have remarkably benefited from automation procedures Since the advent of dedicated robotic platforms, even complete workflows of microwave-assisted syntheses can be fully automated.
Rapid Solid-Phase Synthesis of a Calmodulin-Binding Nonapeptide using Thermal and Controlled Microwave Irradiation
B. Bacsa, B. Desai, G. Dibó1 and C.O. Kappe. Eötvös Loránd University and Karl-Franzens-University Graz
By using the latest developments in microwave technology, we developed various protocols for the synthesis and fluorescently labelling of test peptides under microwave conditions. All synthetic steps were performed under very mild conditions, similar to that is used in traditional solid-phase peptide synthesis. After the final cleavage step, the crude peptide product was subjected to HPLC-MS analysis.
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